The role of endothelin - 1 in mediating changes in cardiac 2 sympathetic nerve activity in heart failure 3 4
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چکیده
The role of endothelin-1 in mediating changes in cardiac 2 sympathetic nerve activity in heart failure 3 4 Yonis Abukar, Clive N May and Rohit Ramchandra. 5 6 Florey Institute of Neuroscience and Mental Health, University of Melbourne, 7 Parkville Victoria, Australia and Department of Physiology, Auckland 8 University, Auckland, New Zealand. 9 10 11 Brief title: Endothelin-1 and CSNA 12 13 14 Total word count: 2365 (excl. abstract, fig legends, references) 15 Address for correspondence: 16 Dr. Rohit Ramchandra, 17 Department of Physiology, 18 Auckland University, 19 Auckland, 1142 20 New Zealand 21 Ph: +64 9 923 5183 22 E: [email protected] 23 24
منابع مشابه
Role of endothelin-1 in mediating changes in cardiac sympathetic nerve activity in heart failure.
Heart failure (HF) is associated with increased sympathetic nerve activity to the heart (CSNA), which is directly linked to mortality in HF patients. Previous studies indicate that HF is associated with high levels of plasma endothelin-1 (ET-1), which correlates with the severity of the disease. We hypothesized that blockade of endothelin receptors would decrease CSNA. The effects of intravenou...
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Endothelins are a family of peptides, which comprises endothelin-1 (ET-1), endothelin-2 (ET-2) and endothelin-3 (ET-3), each containing 21 amino-acids. ET-1 is a peptide secreted mostly by vascular endothelial cells, the predominant isoform expressed in vasculature and the most potent vasoconstrictor currently known. ET-1 also has inotropic, chemotactic and mitogenic properties. In addition, it...
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تاریخ انتشار 2015